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Narrative review · 2017

Why the amount of light matters

A review of how red and near-infrared light affect inflammation. More light is not always better. This review describes why a small dose and a large dose can have different effects.

The main finding. More light is not always better. This review describes why a small dose and a large dose can have different effects.

By Nota Cutis, editorial team · Reviewed

Hamblin MR. AIMS Biophys. 2017;4(3):337–61. PubMed 28748217 · DOI

How the study worked

The author reviewed cell, animal and some human research on red and near-infrared light and inflammation. This area is often called photobiomodulation.

The results

The review describes light absorption in mitochondria, particularly by cytochrome c oxidase, with possible roles for light-sensitive calcium channels. Proposed effects include changes in cell energy, nitric oxide and repair signals.

In stressed cells, studies often found less oxidative stress and fewer inflammatory markers. Small doses may stimulate activity while larger doses may slow it down.

What is still unclear

Much of the research was on cells or animals. Many studies concerned joints, the brain or lungs rather than facial skin.

What to take from this

More light is not always better. This review describes why a small dose and a large dose can have different effects.

Devices that list similar light

Four of the 5 masks in the comparison list a wavelength in every band used here (red, 620–670 nm and near-infrared, 800–870 nm). They are examples, listed alphabetically, each with our specification page and the manufacturer’s own product page. Related devices are examples, not evidence that a study tested that retail model.

These masks list one of the bands, but not all:

Matching a wavelength is not the same as matching the study. Dose, irradiance, session length and schedule also differ, and a mask’s reported output is not independently measured. See how dose works and home vs clinic doses.

We rewrote the source edition’s abstract summary in simpler language. It is not medical advice, and it does not mean any mask reproduces this study’s results. Read the original record on PubMed, and talk to a qualified clinician about your skin.